COMPOSITIONS AND METHODS FOR MODIFYING GENOMES
Application
US20260085301A1
Kind: A1
Mar 26, 2026
Assignee
Confluence Genetics, LLC
Inventors
Matthew Brett Begemann, Emma Elizabeth January, Gina C. Neumann, Allison Jane Newton Antonakos, Anna Singer, Erin Zess
Abstract
Compositions and methods for targeting pre-determined DNA sequences in cells of interest are provided. The methods result in the targeted elimination of cells that comprise the pre-determined DNA sequence(s). Compositions comprise DNA constructs comprising nucleotide sequences that encode a Cas12a2 protein operably linked to a promoter that is operable in the cells of interest. Methods to use these DNA constructs to selectively target and eliminate cells that harbor the targeted DNA sequence(s) are described herein.
CPC Classifications
C12N 9/226
C12N 15/11
C12N 15/8213
C12N 15/86
C12N 15/902
C12N 15/907
C12N 2310/20
C12N 2750/14143
C12N 2800/80
Filing Date
2025-09-19
Application No.
19334505