HETERODIMERIC HUMAN IgG1 POLYPEPTIDES WITH ISOELECTRIC POINT MODIFICATIONS
Application
US20260085132A1
Kind: A1
Mar 26, 2026
Inventors
Gregory L. Moore, Gregory Lazar
Abstract
The invention relates generally to compositions and methods for purifying the desired species from a mixture of desired heterodimer and contaminating homodimer immunoglobulin variants by modifying the isoelectric point(s) of the individual chains.
CPC Classifications
C07K 16/468
C07K 16/00
C07K 14/521
C07K 14/522
C07K 14/523
C07K 14/525
C07K 14/535
C07K 14/54
C07K 14/5428
C07K 14/5434
C07K 14/55
C07K 14/70521
C07K 14/7151
C07K 14/745
C07K 14/755
C07K 16/22
C07K 16/2803
C07K 16/2809
C07K 16/283
C07K 16/2878
C07K 2317/31
C07K 2317/35
C07K 2317/52
C07K 2317/94
C07K 2319/30
Filing Date
2025-11-13
Application No.
19388859