MULTISPECIFIC BINDING CONSTRUCTS AGAINST CHECKPOINT MOLECULES AND USES THEREOF
Application
US20260085121A1
Kind: A1
Mar 26, 2026
Assignee
Compass Therapeutics, LLC
Inventors
Bing GONG, Rachel RENNARD, Amanda Frank OLIPHANT, Cheuk Lun LEUNG, Benjamin Jacob WOLF, Ugur ESKIOCAK, Pearl BAKHRU, Diana I. ALBU
Abstract
The present disclosure relates to compositions and methods for inhibiting tumor evasion by reducing immune checkpoint suppression. In some embodiments, provided herein are compositions that block the interaction between PD-1 and its ligand (e.g., PD-1 and/or PD-L2) while promoting the interaction of the cells on which PD-1 and its ligand are expressed. Also provided are methods of using such compositions.
CPC Classifications
C07K 16/2818
A61P 35/00
C07K 16/2827
A61K 2039/505
C07K 2317/31
C07K 2317/33
C07K 2317/35
C07K 2317/565
C07K 2317/92
Filing Date
2025-11-24
Application No.
19398817