CONJUGATE OF ANTI-CTLA-4 ANTIBODY ACTIVATED BY TUMOR MICROENVIRONMENT AND USE THEREOF

Abstract

A conjugate of an anti-CTLA-4 antibody activated by a tumor microenvironment and an application thereof. The conjugate has the following structure: R1-R2-R3-L-R4-S-cys-R5, wherein R1, R2, R3, L, R4, and R5 each represent structures such as different functional groups, linkers, chemical bonds, and CTLA-4 antibodies. The conjugate is a dual-activated conjugate, which can improve the targeting efficacy of the anti-CTLA-4 antibody while overcoming the drug resistance of the antibody and reducing toxicity.

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