ALL-IN-ONE AGONISTIC ANTIBODIES
Assignee
Hoffmann-La Roche Inc.
Inventors
Petra Elisabeth Marilena BALBI, Jack Anthony BATES, Samuele CALABRO, Laura CODARRI DEAK, Stephan GASSER, Guy GEORGES, Xavier GUERIPEL, Ralf Joerg HOSSE, Christian KLEIN, Stéphane Gérard Alain LECLAIR, Ekkehard MOESSNER, Christian MUELLER, Diana Angela PIPPIG, Laurene POUSSE, Camilla Elizabeth TREVOR, Pablo UMAÑA FERNÁNDEZ
Abstract
The application relates to antigen binding molecules comprising a pair of biparatopic target-binding domains, a pair of cytokine receptor-binding domains and an Fc domain, wherein the target-binding domains simultaneously bind the target antigen and the cytokine receptor-binding domains bind subunits of a cytokine receptor complex. Biparatopic assembly of the cytokine receptor-binding domains in presence of the target antigen allows to selectively activate cytokine receptors and effectively mimic cytokine activity in a targeted manner.
CPC Classifications
Filing Date
2025-10-02
Application No.
19348515