MAGEA4 SPECIFIC T CELL RECEPTORS
Application
US20260085105A1
Kind: A1
Mar 26, 2026
Assignee
AMGEN INC.
Inventors
Sungeun KIM, Matthew James RARDIN
Abstract
Provided herein are recombinant T-cell receptors (TCRs) that can selectively recognize the MAGE-A4-derived peptide GVYDGEEHSV or KVEEHVVRV when presented by HLA-A*0201 sufficiently to activate the recombinant T cell. TCRs provided herein were thoroughly screened for lack of cross-reactivity with similar peptides that may be presented by normal cells or tissue and for alloreactivity.
CPC Classifications
C07K 14/7051
A61K 35/17
A61K 40/11
A61K 40/32
A61K 40/4268
A61P 35/00
C07K 14/5434
C12N 5/0636
C12N 15/867
C07K 2317/33
C07K 2317/565
C07K 2317/72
C12N 2740/15043
Filing Date
2023-06-23
Application No.
18876904