METHODS OF ANTIGEN PRODUCTION
Application
US20260085100A1
Kind: A1
Mar 26, 2026
Assignee
THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY
Inventors
Elizabeth Kennedy Duperret, Alfredo Perales Puchalt, David B. Weiner, Niranjan Y. Sardesai
Abstract
The disclosure relates to methods of manufacturing individualized vaccines that comprise nucleic acid molecules that encode one or more neoantigens specific for antigens that are expressed by a tumor in a subject. Compositions comprising coding regions encoding neoantigens organized in a pattern of nucleic acid sequences are also disclosed as well as methods of immunizing a subject using the same.
CPC Classifications
C07K 14/4748
A61K 39/00
A61K 39/0011
A61K 39/00119
A61K 40/11
A61K 40/4201
A61K 40/4271
A61K 45/06
A61P 35/00
C12Q 1/6886
A61K 2039/53
C12Q 2600/156
Filing Date
2025-05-14
Application No.
19208273