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PEPTIDES THAT SELECTIVELY BIND TO Trop2 AND USE THEREOF

Application US20260085091A1 Kind: A1 Mar 26, 2026

Assignee

KYUNGPOOK NATIONAL UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION

Inventors

Byung-Heon LEE, Uttapol PERMPOON, Peti Thuwajit

Abstract

The present disclosure relates to a peptide binding to Trop 2 and a use thereof, wherein, in an attempt to find a peptide having an ability of specifically binding to Trop 2, a peptide (amino acid sequence: CSTLNVESC (SEQ ID NO: 1)) that selectively binds to Trop 2 was discovered using a phage display technique. Targeting cancers that are highly resistant to anticancer drugs in breast cancer (in particular, triple-negative breast cancer), pancreatic cancer, and cholangiocarcinoma while having no effective treatments, an effective anticancer drug may be prepared by delivering cancer-specific drugs or developing targeted therapeutic agents using the peptide of the present disclosure.

CPC Classifications

C07K 7/06 A61P 35/00 G01N 33/5758 A61K 38/00 C07K 2319/00 G01N 2333/705

Filing Date

2023-08-10

Application No.

19107750