KDM1A INHIBITORS FOR THE TREATMENT OF DISEASE
Application
US20260085082A1
Kind: A1
Mar 26, 2026
Assignee
Imago Biosciences, Inc.
Inventors
Hugh Y. Rienhoff, Jr., Cassandra Celatka, Amy E. Tapper, Nivedita Namdev, Michael Clare
Abstract
Disclosed herein are new compounds and compositions and their application as pharmaceuticals for the treatment of diseases. Methods of inhibition of KDM1A, methods of increasing gamma globin gene expression, and methods to induce differentiation of cancer cells in a human or animal subject are also provided for the treatment of diseases such as acute myelogenous leukemia.
CPC Classifications
C07F 9/65583
A61K 31/4155
A61K 31/454
A61K 31/4545
A61K 31/496
A61K 31/541
A61K 31/675
A61K 31/706
A61P 35/02
C07D 231/40
C07D 401/06
C07D 401/12
C07D 401/14
C07D 403/06
C07D 403/10
C07D 403/12
C07D 405/14
C07D 413/14
C07D 417/14
C07D 491/056
Filing Date
2023-12-15
Application No.
19137840