DERIVATIVE OF HISPIDIN FROM SANGHUANGPORUS SANGHUANG, AND PREPARATION METHOD AND USE THEREOF

Abstract

The present disclosure relates to the technical field of drug synthesis, and particularly relates to a Hispidin derivative, and a preparation method and use thereof. The Hispidin derivative has a structure of formula (I): The present disclosure employs 4-hydroxy-6-methyl-2-pyrone and 3,4-dihydroxybenzaldehyde as starting raw materials to synthesize a series of compounds with styrylpyrone as a backbone. The preparation method provided by the present disclosure has simple steps, is easy to operate, has good feasibility, has the potential for large-scale industrial application, and has a broad market prospect. The present disclosure further provides use of the preparation method described above and the resulting Hispidin derivative in preparation of a lipid-lowering drug. The aryl compound provided by the present disclosure has a good lipid-lowering therapeutic effect and can be used for preparing a lipid-lowering drug, thus having good social benefits.

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