ACSS2 INHIBITORS AND METHODS OF USE THEREOF
Application
US20260085048A1
Kind: A1
Mar 26, 2026
Inventors
Philippe NAKACHE, Omri EREZ, Simone BOTTI, Andreas GOUTOPOULOS, Harry FINCH
Abstract
The present invention relates to novel ACSS2 inhibitors having activity as anti-cancer therapy, treatment of alcoholism, and viral infection (e.g., CMV), composition and methods of preparation thereof, and uses thereof for treating viral infection, alcoholism, alcoholic steatohepatitis (ASH), non-alcoholic steatohepatitis (NASH), obesity/weight gain, anxiety, depression, post-traumatic stress disorder, inflammatory/autoimmune conditions and cancer, including metastatic cancer, advanced cancer, and dmg resistant cancer of various types.
CPC Classifications
C07D 231/22
A61K 31/4152
A61K 31/4155
A61K 31/4184
A61K 31/422
A61K 31/427
A61K 31/4439
A61K 31/454
A61K 31/497
A61K 31/506
A61K 45/06
A61P 3/00
A61P 25/00
A61P 29/00
A61P 31/12
A61P 35/00
A61P 37/02
C07D 231/20
C07D 231/26
C07D 233/70
C07D 401/04
C07D 401/10
C07D 401/12
C07D 401/14
C07D 403/04
C07D 403/10
C07D 403/12
C07D 405/04
C07D 405/10
C07D 405/12
C07D 405/14
C07D 409/04
C07D 409/12
C07D 413/10
C07D 413/12
C07D 413/14
C07D 417/12
C07F 5/025
Filing Date
2025-09-08
Application No.
19321644