COMPOSITIONS TARGETING ENDOTHELIAL CELLS AND USES THEREOF

Abstract

Provided herein are compositions, including pharmaceutical compositions, comprising a binder, linker, and a radioactive isotope, and optionally a masking moiety. The compositions can also comprise a first binder connected to a second binder via a first linker, or a binder connected to a payload via a first linker. In some embodiments, the binder or first binder may specifically bind to a protein (e.g., PMEPA-1) expressed on an endothelial cell. Also provided herein are cells comprising a binder that binds to a protein expressed on an endothelial cell. Also provided herein are engineered immune cells comprising a polynucleotide that encodes a chimeric antigen receptor (CAR) that binds to a protein expressed on an endothelial cell. Also provided herein are methods for using these compositions for selective delivery to cells, treating diseases and disorders, and imaging. In some embodiments, the method comprises administering to the subject an effective amount of the composition disclosed herein.

CPC Classifications