SUSTAINED TRANSGENE EXPRESSION OF MODIFIED ERT2 PEPTIDE-SUICIDE PROTEIN FUSION POLYPEPTIDES
Application
US20260083859A1
Kind: A1
Mar 26, 2026
Inventors
Rebecca Tayler Cottman, Michelle Elizabeth Hung, Russell Morrison Gordley, Timothy Kuan-Ta Lu, Stefan Irion, Mark Tomishima, Chew-Li Soh, Conor McAuliffe
Abstract
Provided herein are targeting constructs for sustained transgene expression of inducible cell death systems that include mutants of estrogen receptor alpha ligand binding domain (ER-LBD). Also provided are methods for use of the same, such as inducing cell death in a cell.
CPC Classifications
A61K 48/005
A61P 37/02
C07K 14/4702
C07K 14/721
C12N 9/222
C12N 9/6472
C12N 15/111
C12N 15/62
C12N 15/85
C07K 2319/715
C12N 2310/20
C12N 2840/203
C12Y 304/22062
Filing Date
2025-07-31
Application No.
19287644