IMMUNOCONJUGATES
Application
US20260083855A1
Kind: A1
Mar 26, 2026
Assignee
Hoffmann-La Roche Inc.
Inventors
Laura CODARRI DEAK, Anne FREIMOSER-GRUNDSCHOBER, Ralf Joerg HOSSE, Christian KLEIN, Ekkehard MOESSNER, Valeria GONZALEZ NICOLINI, Pablo UMAÑA FERNÁNDEZ, Inja WALDHAUER
Abstract
The present invention generally relates to immunoconjugates, particularly immunoconjugates comprising a mutant interleukin-2 polypeptide and an antibody that binds to PD-1. In addition, the invention relates to polynucleotide molecules encoding the immunoconjugates, and vectors and host cells comprising such polynucleotide molecules. The invention further relates to methods for producing the mutant immunoconjugates, pharmaceutical compositions comprising the same, and uses thereof.
CPC Classifications
A61K 47/6813
A61K 47/6849
A61K 47/6889
A61P 35/00
C07K 14/55
C07K 16/2818
A61K 38/00
C07K 2319/00
Filing Date
2025-07-11
Application No.
19267102