POLYNUCLEOTIDES TARGETING NR4A3 AND USES THEREOF
Application
US20260083846A1
Kind: A1
Mar 26, 2026
Assignee
Lyell Immunopharma, Inc.
Inventors
Viola LAM, Rachel Christina LYNN
Abstract
The present disclosure provides polynucleotides that are capable of reducing the level of a NR4A3 gene and/or NR4A3 protein in a cell (e.g., immune cell). In some aspects, the polynucleotides comprises a gRNA that specifically targets a region within the NR4A3 gene. The present disclosure also provides the use of such polynucleotides to treat various diseases or disorders.
CPC Classifications
A61K 40/31
A61K 35/14
A61K 40/32
A61K 40/42
A61K 45/06
A61P 35/00
C07K 14/7051
C07K 16/00
C12N 5/0634
C12N 5/10
C12N 9/226
C12N 15/113
C12N 2310/20
C12N 2510/00
Filing Date
2023-05-19
Application No.
18867057