METHODS FOR ABLATING MYELOID DERIVED SUPPRESSOR CELLS USING NEO-201 ANTIBODY

Abstract

NEO-201, an antibody that specifically binds to glycosylated peptides carrying core-1 and/or extended core-1 O-glycans comprised in CEACAM5 and CEAMCAM6 but not to aglycosylated CEACAM5 or aglycosylated CEAMCAM6 surprisingly has been shown to bind to and kill granulocyte myeloid derived suppressor cells (gMDSCs). gMDSCs are known to suppress innate immunity in different cancers and infectious diseases, among other conditions. Based thereon the use of NEO-201 alone or in combination for treating cancers and infectious diseases and other conditions wherein gMDSCs suppress innate immunity against the disease are provided. These methods optionally include detecting gMDSCs before, during or after NEO-201 treatment. Diagnostic methods, therapeutic methods, and combination therapies using NEO-201 optionally in combination with another agent in order to ablate gMDSCs and disease cells are also described.

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