GENERATION OF CD4 T CELLS

Abstract

The technology described herein is directed to methods of generating CD4+CD8− single-positive T cells from CD4+CD8+ double positive T progenitor cells using differentiation in the presence of interleukin-7 (IL-7) and an anti-CD3 agent and in absence of Notch ligand and an anti-CD28 agent. Also described herein are CD4+CD8− single-positive T cells made by the methods described herein, which can be used for therapeutic applications.

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