CITRULLINATED ANTIGEN-SPECIFIC CHIMERIC ANTIGEN RECEPTORS FOR TARGETING REGULATORY T CELLS TO TREAT HIDRADENITIS SUPPURATIVA
Application
US20260083777A1
Kind: A1
Mar 26, 2026
Assignee
Sonoma Biotherapeutics, Inc.
Inventors
Leonard DRAGONE, Joshua BEILKE
Abstract
Disclosed herein are chimeric antigen receptors (CARs) comprising an antigen binding site that recognizes citrullinated polypeptides. Citrullinated polypeptides, such as citrullinated vimentin, are expressed in the skin lesions of subjects with hidradenitis suppurativa. Further disclosed are T cells, and in particular, Treg cells that express these CARs. Administration of these CAR-T cells is useful in the treatment of hidradenitis suppurativa.
CPC Classifications
A61K 35/17
A61K 40/11
A61K 40/31
A61K 40/416
C07K 14/535
C07K 14/7051
C07K 14/70517
C07K 14/70521
C07K 16/18
C12N 5/0637
A61K 2239/13
A61K 2239/17
A61K 2239/21
C07K 2317/53
C07K 2317/565
C07K 2317/622
C07K 2319/02
C07K 2319/03
C12N 2510/00
Filing Date
2023-09-18
Application No.
19112106