ACTIVATION AND PROLIFERATION OF CYTOTOXIC LYMPHOCYTES
Application
US20260083776A1
Kind: A1
Mar 26, 2026
Inventors
Mark SCHVARTZMAN, Angel PORGADOR, Ashish PANDEY, Carlos Ureña MARTIN, Guillaume LE SAUX
Abstract
Disclosed herein are micropatterned surfaces, particularly in the shape of micro-brushes having a base and a plurality of elongated elements. The micropatterned surfaces suitably biofunctionalized are particularly useful for activation and expansion of cells. Methods for activation and expansion of cytotoxic lymphocytes with decreased exhaustion potential are also provided, as well as means involving same to treat a patient in need thereof.
CPC Classifications
A61K 35/17
A61K 40/11
A61K 40/31
A61P 35/00
C12N 5/0018
C12N 5/0638
C12N 9/226
C12N 15/111
C12N 15/87
C12N 2310/20
C12N 2501/2301
C12N 2501/2302
C12N 2501/2304
C12N 2501/2306
C12N 2501/2307
C12N 2501/231
C12N 2501/2312
C12N 2501/2315
C12N 2501/2318
C12N 2501/25
C12N 2501/51
C12N 2501/515
C12N 2510/00
C12N 2533/30
C12N 2533/50
C12N 2535/10
Filing Date
2023-09-05
Application No.
19108842