ALLOSTERIC MODULATORS OF ANDROGEN RECEPTOR COACTIVATOR RECRUITMENT FOR CRPC THERAPY
Application
US20260083751A1
Kind: A1
Mar 26, 2026
Assignee
University of Pittsburgh – Of the Commonwealth System of Higher Education
Inventors
Paul A. Johnston, Andrew P. Hinck, Carlos J. Camacho, Peter Wipf, Zhou Wang, Lee A. McDermott
Abstract
Small molecule allosteric modulators of androgen receptor are disclosed. The compounds may inhibit androgen receptor coactivator recruitment, such as by preventing formation of protein-protein interaction (PPI) complexes and/or disrupting PPI complexes. A method of treating prostate cancer, such as castration-resistant prostate cancer, includes administering a small molecule allosteric modulator of androgen receptor.
CPC Classifications
A61K 31/553
A61K 31/4045
A61K 31/4155
A61K 31/4439
A61K 31/454
A61K 31/497
A61K 31/501
A61P 35/00
Filing Date
2023-08-30
Application No.
19108095