GHRELIN O-ACYL TRANSFERASE (GOAT) INHIBITORS FOR USE IN THE TREATMENT OF SUBSTANCE USE DISORDER IN PATIENTS WITH HIGH IMPULSIVITY
Application
US20260083736A1
Kind: A1
Mar 26, 2026
Inventors
Stefan JUST, Hugo CRUCES SOLIS, Johann Faustus DU HOFFMANN, Jennifer Buenzle DWYER, Janet Rachel NICHOLSON, Katrin Hildegund PRELLER
Abstract
The present invention relates to compounds of general formula I, wherein the groups R1, R2 and n are defined herein, which are ghrelin O-acyl transferase (GOAT) inhibitors. The invention also relates to the use of compounds of formula (I) for treatment of substance use disorder (SUD,) in particular for use in the treatment of opioid use disorder (OUD) or stimulant use disorder (StimUD), in patients with high impulsivity.
CPC Classifications
A61K 31/506
A61K 31/437
A61K 31/444
A61K 31/497
A61K 31/5377
A61K 31/551
Filing Date
2025-09-22
Application No.
19335420