METHODS FOR TREATMENT OF BONE MARROW FAILURE AND RELATED CONDITIONS

Abstract

Provided herein are methods for increasing the numbers of hematopoietic stem cells (HSCs) in a patient in need thereof, for treating a condition characterized by reduced numbers of hematopoietic stem cells (HSCs), such as bone marrow failure (BMF) or a BMF syndrome, in a patient in need thereof, for enhancing recovery from or improving tolerance of a near-ablative cancer therapy, and/or for reducing the damage to, or accelerating the recovery of, the hematopoietic compartment after a physical insult thereto in a patient in need thereof, comprising administering in vivo or treating cells ex vivo with an LSD1 inhibitor.

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