METHODS OF PERMEABILIZING THE BLOOD BRAIN BARRIER
Application
US20260083685A1
Kind: A1
Mar 26, 2026
Assignee
UNIVERSITY OF SOUTHERN CALIFORNIA
Inventors
Thomas Chen
Abstract
The present invention relates to using monoterpene or sesquiterpene to permeabilize the blood brain barrier. The present invention relates to a method of treating a central nervous system (CNS) cancer wherein perillyl alcohol (POH) is administered to a mammal before or concurrently with a therapeutic agent that is a chimeric antigen receptor T-cell (CAR-T cell). The POH and CAR-T cells can be administered by intraarterial injection. The CNS cancer can be a malignant glioma, pilocytic astrocytomas (grade I), meningiomas, metastatic brain tumors, or pituitary adenomas.
CPC Classifications
A61K 31/045
A61K 9/0019
A61K 9/0043
A61K 9/0078
A61K 9/0085
A61K 31/4015
A61K 31/415
A61K 31/4188
A61K 31/4745
A61K 39/3955
A61K 40/11
A61K 40/31
A61K 40/4211
A61K 45/06
A61P 35/00
C07K 14/70503
C07K 16/2809
C07K 16/42
C12N 5/0638
A61K 2039/505
A61K 2039/54
A61K 2039/543
A61K 2039/544
A61K 2039/545
A61K 2239/31
A61K 2239/38
A61K 2239/48
C07K 2317/52
C12N 5/16
C12P 5/007
Filing Date
2025-12-05
Application No.
19410039