CLINICAL PATHOLOGIC DATA-FREE AND COMPUTER-AIDED PREDICTION SYSTEM FOR GENETIC VARIATION PATHOGENICITY AND INHERITANCE PATTERN THEREOF AND METHOD THEREOF, AND ION SELECTION SYSTEM AND METHOD THEREOF

Abstract

A clinical pathologic data-free and computer-aided prediction method for genetic variation pathogenicity and an inheritance pattern thereof includes a molecular dynamics (MD) simulation step, a computing step, a determination step, and a predicted result production step. The MD simulation step is to perform molecular modeling and computational simulations on channel protein configurations, where the channel protein configurations include a wild-type channel or mutated channels. The computing step is to compute the number of ions passing through the wild-type channel and the number of ions passing through the mutated channel, respectively to obtain a first ion number and a second ion number within a predetermined period. The determination step is to determine the class of each mutated channel according to the first ion number and the second ion number. The predicted result production step is to produce a predicted result according to the classes of the mutated channels.

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