METHODS AND SYSTEMS FOR PREDICTING A DISEASE STATE BASED ON ANALYZING CFDNA FRAGMENTS

Abstract

Methods for predicting a disease based on analyzing cfDNA fragments are described. The methods may comprise, for example, determining, by one or more processors, a test count of methylated loci for cfDNA fragments within a size range for a test sample obtained from a subject; determining, by the one or more processors, a disease score based on comparing the test count of the methylated loci to a reference count of methylated loci from one or more reference samples; and predicting, by the one or more processors, the disease state for the subject based on a comparison of the disease score to a predetermined disease score threshold.

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