CD127 EXPRESSION INVERSELY CORRELATES WITH FOXP3 AND SUPPRESSIVE FUNCTION OF CD4+ TREGS
Application
US20260079159A1
Kind: A1
Mar 19, 2026
Inventors
Jeffrey A. BLUESTONE, Weihong LIU, Amy PUTNAM
Abstract
The invention provides methods of isolating CD127lo/− immunosuppressive regulatory T cells which can be greatly enriched for FoxP3, methods of expanding the isolated cells, pharmaceutical compositions of such cells, and methods of their use in the treatment of autoimmune and other immune system mediated disorders.
CPC Classifications
G01N 33/56972
A61K 39/0008
A61K 40/11
A61K 40/22
A61K 40/416
C12N 5/0636
G01N 33/505
A61K 2035/122
A61K 2039/515
G01N 2333/70514
G01N 2333/70517
G01N 2333/70596
G01N 2333/7155
Filing Date
2025-09-12
Application No.
19327150