APPARATUS, SYSTEM, AND METHOD FOR HIGH YIELD MAGNETIC SEPARATION OF A BIOLOGICAL POPULATION

Abstract

The present disclosure provides systems, methods, and apparatuses for improved magnetic separation of a biological population. A system for magnetic separation and collection of a target biological population from a biological sample comprises a cell engineering cassette, and a fluidic pathway disposed within the cell engineering cassette. The fluidic pathway has entrapment features disposed along a flow path of the fluidic pathway. An array of magnets is disposed adjacent to the fluidic pathway and the cell engineering cassette such that the array of magnets can be translatable toward and away from the fluidic pathway to apply a magnetic field to the biological population for the separation of a first subpopulation from a second subpopulation.

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