ORTHOGONAL METABOLIC FRAMEWORK FOR ONE-CARBON UTILIZATION
Application
US20260078416A1
Kind: A1
Mar 19, 2026
Inventors
Ramon Gonzalez, Alexander Chou, James MacAllister Clomburg, Fayin Zhu, Seung Hwan Lee, Mohammadreza Nezamirad
Abstract
Provided are systems and methods for converting C1 substrates to products contain more than one carbon, without producing central metabolic building blocks as intermediate products. In an embodiment, system/method can include a biochemical pathway enabling an orthogonal platform for C1 utilization based on formyl-CoA elongation (FORCE) reactions. In an embodiment, the system/method can include acyloin condensations between formyl-CoA and carbonyl-containing molecules. In an embodiment, the system/method can include a reactions catalyzed by the enzyme 2-hydroxyacyl-CoA lyase (HACL).
CPC Classifications
C12P 7/42
C12N 9/1025
C12N 9/1029
C12N 9/88
C12N 9/93
C12N 15/70
C12P 7/56
C12Y 203/01023
C12Y 401/01008
C12Y 602/01003
C12N 2800/101
Filing Date
2022-08-16
Application No.
18442550