Genome Editing Method for Duplicated Genes
Application
US20260078392A1
Kind: A1
Mar 19, 2026
Assignee
NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY
Inventors
Shigeo Sugano, Reika Hasegawa
Abstract
The purpose of the present invention is to provide a technology for, by using a small number of gRNA or crRNA, simultaneously editing numerous genes that are functionally duplicated. It was found that a CasĪ¦ protein derived from huge phages can cut a target sequence having a nucleotide length of 16 or more, and a mismatch sequence including a mismatch of 1 or 2 bases with respect to the target sequence. Accordingly, provided is a genome editing method that is for duplicated genes and that uses said CasĪ¦ protein.
CPC Classifications
C12N 15/8213
C12N 9/226
C12N 15/11
C12N 2310/20
Filing Date
2023-09-06
Application No.
19109216