Methods for Directing Lipid Nanoparticles in Vivo
Application
US20260078381A1
Kind: A1
Mar 19, 2026
Assignee
Vertex Pharmaceuticals Incorporated
Inventors
Gregoriy Aleksandrovich Dokshin, Souvik Biswas
Abstract
Compositions and methods for enhancing payload-based gene therapy by increasing the percentage of payload delivered to a non-liver target in a subject by blocking binding of LDL to LDL receptors (LDLR) in the liver, and then administering a payload-based therapy targeting a non-liver tissue.
CPC Classifications
C12N 15/1138
C12N 2310/14
C12N 2310/351
C12N 2310/3515
Filing Date
2025-11-25
Application No.
19400453