CONSTRUCT COMPRISING UTR SEQUENCE THAT IMPROVES INTRACELLULAR STABILITY AND BIOSYNTHESIS OF MRNA AND USE THEREOF

Abstract

Unlike DNA, mRNA has the advantage of enabling transient expression of a desired protein directly in the cytoplasm without having to enter the nucleus, and thus, attempts to use mRNA vaccines are actively underway. However, mRNA has lower structural stability than DNA, and thus has limitations in industrial application. Therefore, the present invention relates to a UTR sequence that improves the intracellular stability and biosynthesis of mRNA, and a composition for stabilizing nucleic acids, comprising the UTR sequence. The UTR sequence of the present invention has excellent effects of stabilizing nucleic acids and promoting the expression of a target protein, and thus is expected to be greatly used in the health/medical field.

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