Cyclic Antisense Therapeutics
Application
US20260078373A1
Kind: A1
Mar 19, 2026
Inventors
Sudhir AGRAWAL, Vinod VATHIPADIEKAL
Abstract
The present invention provides oligonucleotides referred to as cyclic structured oligonucleotides (“CSOs”) comprising a functional domain, a cyclizing domain, and a linker segment as described herein, compositions comprising same, and methods of using same. This design of cyclic oligonucleotides maintains a cyclic form until it is in the presence of and hybridizes with a targeted RNA.
CPC Classifications
C12N 15/113
A61K 31/7105
A61K 31/711
A61K 31/712
A61K 31/7125
C12N 2310/11
C12N 2310/315
C12N 2310/321
C12N 2310/346
C12N 2310/3525
C12N 2310/532
Filing Date
2025-09-19
Application No.
19334208