DNA POLYMERASE MUTANT FOR SEQUENCING
Application
US20260078358A1
Kind: A1
Mar 19, 2026
Assignee
WUHAN MGI TECH CO., LTD.
Inventors
Fen LIU, Siqian HUANG, Liyuan YANG, Jing GAO, Jiakun BAI, Yang XIAO, Juan YANG, Xiang SU, Yuepeng LIU, Chengwei SONG
Abstract
Provided is a DNA polymerase mutant for sequencing. The DNA polymerase mutant includes: compared with a Pyrococcus abyssi DNA polymerase exo-mutant, at least three amino acid mutations in the following four sites or functionally equivalent sites: position 409, position 410, position 411, and position 486. The Pyrococcus abyssi DNA polymerase exo-mutant has an amino acid sequence as set forth in SEQ ID NO: 1.
CPC Classifications
C12N 9/1252
C12N 1/20
C12N 15/70
C12P 19/34
C12Q 1/6869
C12R 2001/19
C12Y 207/07007
Filing Date
2025-11-26
Application No.
19401896