COMPOSITIONS FOR PROMOTING ACTIVATION OF BONE MARROW-DERIVED STEM CELLS COMPRISING CCL5
Application
US20260078344A1
Kind: A1
Mar 19, 2026
Assignee
PUSAN NATIONAL UNIVERSITY INDUSTRY-UNIVERSITY COOPERATION FOUNDATION
Inventors
Dongjun Lee, Soo-Yeon Woo
Abstract
The present disclosure relates to a composition for promoting the activation of bone marrow-derived stem cells, including C-C motif chemokine ligand 5 (CCL5), wherein, when CCL5 is administered together with growth-related oncogene beta (GROβ) and AMD3100, it not only increases the migration of hematopoietic stem cells from bone marrow to peripheral blood, but also enhances the engraftment efficiency when the hematopoietic stem cells are transplanted into recipients.
CPC Classifications
C12N 5/0647
A61K 35/28
A61P 19/08
C12N 2501/10
C12N 2501/21
C12N 2501/999
Filing Date
2025-08-19
Application No.
19303355