SCAFFOLDS WITH STABILIZED MHC MOLECULES FOR IMMUNE-CELL MANIPULATION
Application
US20260078340A1
Kind: A1
Mar 19, 2026
Inventors
Sine Reker Hadrup, Soren Nyboe Jakobsen, Sunil Kumar Saini
Abstract
The present invention relates to artificial antigen presenting cell (aAPC) scaffolds to provide cells with specific functional stimulation to obtain phenotypic and functional properties ideal to mediate tumor regression or viral clearance. In particular, the scaffolds of the present invention comprise stabilized MHC class I molecules free of antigenic peptide. The scaffolds can be loaded with antigenic peptide on demand, providing an agile platform for effective expansion and functional stimulation of specific T cells in a peptide-MHC-directed fashion.
CPC Classifications
C12N 5/0636
A61K 40/11
A61K 40/42
A61P 17/00
A61P 35/00
A61K 2039/876
A61K 2239/31
A61K 2239/57
C12N 2501/2302
C12N 2501/2315
C12N 2501/2321
C12N 2501/50
Filing Date
2025-10-29
Application No.
19373494