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ORTHOGONAL MUTATIONS FOR HETERODIMERIZATION

Application US20260078202A1 Kind: A1 Mar 19, 2026

Inventors

Jonathan Harry DAVIS, Nicholas M. MARSHALL

Abstract

Heterodimerizing domains with orthogonal mutations that drive heterodimerization, in particular heterodimerizing antibody CH3 domains, heterodimeric polypeptides comprising such heterodimerizing domains, and antibody constructs comprising such heterodimeric polypeptides, are provided.

CPC Classifications

C07K 16/468 A61K 39/00 C07K 2317/31 C07K 2317/35 C07K 2317/50 C07K 2317/526 C07K 2317/56 C07K 2317/569 C07K 2317/60 C07K 2317/64

Filing Date

2025-04-25

Application No.

19190527