GENETICALLY MODIFIED NON-HUMAN ANIMALS AND METHODS FOR PRODUCING HEAVY-CHAIN ANTIBODIES
Application
US20260078197A1
Kind: A1
Mar 19, 2026
Inventors
Yiqing Hu, Qi Zhang, Lijun Zhang, Yabo Zhang, Huizhen Zhao, Jiawei Yao, Yuelei Shen
Abstract
The present disclosure relates to genetically modified animals and methods for producing heavy-chain antibodies. In one aspect, the genetically modified non-human animal comprises a modified immunoglobulin heavy chain locus, wherein the modified immunoglobulin heavy chain locus comprises an IgG constant region gene, wherein the IgG constant region gene encodes an IgG heavy chain constant region lacking a CH1 domain, wherein the genetically modified non-human animal expresses a heavy-chain antibody. Also disclosed herein are anti-TFR1 antibodies, antigen-binding fragments, and the uses thereof.
CPC Classifications
C07K 16/2881
A01K 67/0276
A01K 67/0278
C12N 15/8509
A01K 2217/072
A01K 2217/075
A01K 2227/105
A01K 2267/01
C07K 2317/24
C07K 2317/33
C07K 2317/92
C07K 2317/94
C12N 2015/8518
Filing Date
2023-09-15
Application No.
19108869