MULTISPECIFIC CONSTRUCTS AND USES THEREOF

Abstract

Provided are bispecific and multi-specific antibodies that include an agonist anti-4-1BB single-domain antibody capable of effector function-mediated tumor inhibition. In addition, these agonist antibodies, in the absence of tumor antigen-expressing cells, bind to 4-1BB but are unable to activate 4-1BB signaling. In the presence of a tumor antigen-expressing cell, however, these antibodies can trigger tumor antigen-dependent 4-1BB signaling, leading to potent immune response to the tumor antigen-expressing tumor cells.

CPC Classifications