Bispecific Tetravalent Antibodies and Methods of Making and Using Thereof
Application
US20260078190A1
Kind: A1
Mar 19, 2026
Assignee
SystImmune, Inc.
Inventors
Zeren Gao, Phil Tan, Brian R. Kovacevich, Blair R. Renshaw, Jeffrey B. Adamo, Nga Sze Amanda Mak, Shi Zhuo, Lan Chen, Yi Zhu
Abstract
A bispecific tetravalent antibody comprising an lgG having a pair of heavy chains and a pair of light chains, and two scFv components being connected to either C or N terminals of the heavy or light chains. The bispecific tetravalent antibody may have a binding specificity for two different members of EGFR family.
CPC Classifications
C07K 16/2863
A61K 31/337
A61K 33/243
A61K 45/06
A61K 47/6843
A61P 35/00
C07K 14/70521
C07K 14/70532
C07K 14/70578
C07K 16/32
A61K 2039/505
Filing Date
2025-08-27
Application No.
19311740