TREATING CHRONIC INFLAMMATION AND CANCER BY MACROPHAGE POLARIZATION
Application
US20260078183A1
Kind: A1
Mar 19, 2026
Inventors
Zhi-Ren LIU, Guangda PENG
Abstract
A method for treating a disease or disorder includes administering to a subject an effective amount of an agent that promotes the polarization of macrophages. The macrophages selectively repolarize their phenotype in the microenvironment. The agent can be PKM2 or mutant thereof. Further, wherein administration of the agent reduces inflammation in the subject.
CPC Classifications
C07K 16/2818
A61K 38/45
A61P 35/00
C07K 16/40
C12Y 207/0104
C07K 2317/76
Filing Date
2023-08-28
Application No.
19106336