METHODS AND COMPOSITIONS FOR INCREASING IDURONATE 2-SULFATASE ACTIVITY IN THE CNS
Application
US20260078178A1
Kind: A1
Mar 19, 2026
Inventors
William M. Pardridge, Ruben J. Boado
Abstract
Provided herein are methods and compositions for treating a subject suffering from a deficiency in iduronate 2-sulfatase in the CNS. The methods include systemic administration of a bifunctional fusion antibody comprising an antibody that crosses the blood brain barrier (BBB) and an iduronate 2-sulfatase.
CPC Classifications
C07K 16/18
C07K 16/2869
C12N 9/16
A61K 38/00
A61K 2039/505
C07K 2317/565
C07K 2317/92
C07K 2319/30
C07K 2319/33
C12Y 301/06013
Filing Date
2025-11-26
Application No.
19401802