CONNEXIN (Cx)43 HEMICHANNEL-BINDING ANTIBODIES AND USES THEREOF
Application
US20260078177A1
Kind: A1
Mar 19, 2026
Inventors
JEAN X. JIANG, ZHIQIANG AN, NINGYAN ZHANG, WEI XIONG, MANUEL A. RIQUELME, SUMIN GU, NAOMI LEDENE SAYRE
Abstract
Antibodies that bind to connexin 43 hemichannels and inhibit, or activate, channel opening are provided. In certain aspects, methods for detecting or treating cancers with antibodies that activate Cx43 channel opening are also provided. Likewise, methods for treating inflammatory diseases (e.g., osteoarthritis) and neurological injuries (e.g., spinal cord injury) with antibodies that inhibit Cx43 channel opening are provided.
CPC Classifications
C07K 16/18
A61K 39/395
A61P 19/10
A61P 25/28
A61P 35/00
C07K 2317/24
C07K 2317/75
C07K 2317/76
Filing Date
2025-11-25
Application No.
19401172