T-CELL RECEPTOR THAT TARGETS EGFR MUTATION AND METHODS OF USING THE SAME
Application
US20260078163A1
Kind: A1
Mar 19, 2026
Inventors
Alexandre REUBEN, Minying ZHANG, John HEYMACH, Greg LIZEE, Peixin JIANG, Patrick HWU
Abstract
The present disclosure relates to an engineered T-cell Receptors (TCRs) capable of binding to an epitope of an epidermal growth factor receptor (EGFR) comprising a T790M mutation presented on human leukocyte antigen-A (HLA-A)*02:01, wherein the epitope comprises the amino acid sequence of MQLMPFGCLL (SEQ ID NO: 1). Also disclosed are Tcell and BiTE therapies comprising the same, and methods of treating EGFR-TKI resistant lung cancers using the same.
CPC Classifications
C07K 14/7051
A61K 35/17
A61K 38/00
A61K 40/11
A61K 40/15
A61K 40/32
A61K 40/4204
A61P 35/00
C12N 5/0087
C12N 5/0636
C12N 5/0646
C12N 15/11
C12N 15/63
A61K 2239/55
C07K 2317/24
C07K 2317/31
C07K 2317/565
Filing Date
2023-09-06
Application No.
19109491