TREATMENT OF NERVOUS SYSTEM INJURY AND NEURODEGENERATIVE DISORDERS AND RELATED CONDITIONS
Application
US20260078156A1
Kind: A1
Mar 19, 2026
Inventors
Yu-Shang LEE, Ching-Yi LIN
Abstract
Provided herein are compositions, systems, kits, and methods for treating nervous system injuries caused by trauma or neurodegeneration or aging in a subject by administering a CSPG or SOCS3 reduction peptide (CRP and SRP respectively), or a nucleic acid sequence encoding the CRP or SRP, wherein both the CRP and SRP comprise a cell membrane penetrating domain, and a lysosome targeting domain, and the CRP further comprises a chondroitin sulfate proteoglycan (CSPG) binding domain, and the SRP further comprises a suppressor of cytokine signaling-3 (SOCS3) binding domain.
CPC Classifications
C07K 14/4703
A61K 9/0019
A61K 31/727
A61P 25/00
A61P 25/28
C07K 19/00
A61K 31/737
A61K 38/00
A61K 38/16
A61K 38/1709
A61K 38/39
A61K 2039/55516
A61K 2039/6031
A61K 47/42
A61K 47/64
A61K 47/645
A61K 48/005
A61K 49/0056
A61K 49/14
A61K 2121/00
A61K 2300/00
A61L 27/22
A61L 2300/236
A61L 2300/252
A61L 2430/32
A61P 17/02
C07K 2319/03
C07K 2319/70
C07K 2319/95
G01N 33/5058
G01N 33/68
Filing Date
2025-07-09
Application No.
19264288