Macrocyclic Compounds as RAS Inhibitors
Application
US20260078134A1
Kind: A1
Mar 19, 2026
Assignee
BeOne Medicines I GmbH
Inventors
Jing Li, Yian Guo, Sanjia Xu, Zhiwei Wang
Abstract
Provided herein are compounds having the following structure: or pharmaceutically acceptable salts, hydrates, or solvates thereof, wherein the substituents are as defined herein, their pharmaceutical compositions and uses for modulating the activity of multiple RAS mutants.
CPC Classifications
C07D 513/22
A61K 31/504
A61K 31/5377
A61K 31/5383
A61K 31/5386
A61K 31/551
C07D 519/00
Filing Date
2025-09-18
Application No.
19332430