RAS INHIBITORS
Application
US20260078133A1
Kind: A1
Mar 19, 2026
Inventors
John E. KNOX, Elena S. KOLTUN, Dylan E. PARSONS, Aidan TOMLINSON, G. Leslie BURNETT, James CREGG, Adrian L. GILL, Andreas BUCKL
Abstract
The disclosure features macrocyclic compounds, and pharmaceutical compositions and protein complexes thereof, capable of inhibiting Ras proteins, and their uses in the treatment of cancers.
CPC Classifications
C07D 498/18
A61K 31/4439
A61K 31/444
A61K 31/496
A61K 31/504
A61K 31/5386
A61K 31/551
A61K 45/06
C07D 498/22
C07D 513/18
C07D 513/20
C07D 513/22
C07D 515/18
C07D 519/00
Filing Date
2025-11-21
Application No.
19396666