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PYRROLO-PYRIDAZINE INHIBITORS OF JAK2

Application US20260078131A1 Kind: A1 Mar 19, 2026

Inventors

Craig E. Masse, Jiayi Xu, Phani Ghanakota, Kevin Robert DeMarco, Susanta Haldar, Alice Hooper

Abstract

The present disclosure provides pyrrolo-pyridazine compounds and compositions thereof useful for inhibiting JAK2. In some embodiments, the present disclosure provides a compound of formula I: or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, and R4 are as defined in classes and subclasses herein, both singly and in combination.

CPC Classifications

C07D 487/14 C07B 59/002 C07D 498/22 C07D 519/00

Filing Date

2025-09-05

Application No.

19320373