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NAMPT MODULATORS, PREPARATIONS, AND USES THEREOF

Application US20260078130A1 Kind: A1 Mar 19, 2026

Inventors

Xiaoqing WANG, Weijie HOU, Ming JIANG, Shaoqiang YANG, Tao SHENG, Guangxin LI, Jie LU, Yingtao LIU, Yu CHEN, Lianzhu LIU, Yimin JIANG, Yanping XU, Zhiyuan ZHANG

Abstract

This disclosure provides compounds of Formula 1 or 8, compositions comprising the same, and methods of using the same, including uses in modulating NAMPT and treating various diseases and conditions that are responsive to NAMPT activation.

CPC Classifications

C07D 487/10 A61K 31/4035 A61K 31/4155 A61K 31/416 A61K 31/4184 A61K 31/4192 A61K 31/422 A61K 31/423 A61K 31/4245 A61K 31/427 A61K 31/428 A61K 31/429 A61K 31/433 A61K 31/437 A61K 31/4439 A61K 31/444 A61K 31/454 A61K 31/4704 A61K 31/4725 A61K 31/4985 A61K 31/501 A61K 31/506 A61K 31/517 A61K 31/5377 A61K 31/538 C07B 59/002 C07D 209/46 C07D 209/48 C07D 215/227 C07D 217/24 C07D 231/56 C07D 265/36 C07D 401/06 C07D 401/12 C07D 401/14 C07D 403/04 C07D 403/06 C07D 403/12 C07D 403/14 C07D 405/14 C07D 413/06 C07D 413/14 C07D 417/06 C07D 417/14 C07D 471/04 C07D 487/04 C07D 491/107 C07D 498/04 C07D 513/04 C07B 2200/05

Filing Date

2023-09-22

Application No.

19109179