INDAZOLE COMPOUNDS AS PKMYT1 KINASE INHIBITORS
Application
US20260078122A1
Kind: A1
Mar 19, 2026
Assignee
Hoffmann-La Roche Inc.
Inventors
Bo CHEN, Fabian DEY, Xiaofeng LIU, Tong MU, Xuefei TAN, Jun WU, Jiasu XU, Dan ZHAO
Abstract
The present invention provides novel compounds having the general formula: wherein R1, R2, R3, R4, A1, A2, A3, and A4 are as described herein, or a pharmaceutically acceptable salt thereof, compositions including the compounds and methods of using the compounds.
CPC Classifications
C07D 471/04
A61K 31/4375
A61K 31/444
A61K 31/4545
A61K 31/4709
A61K 31/496
A61K 31/4985
A61K 31/4995
A61K 31/501
A61K 31/519
A61K 31/5377
C07B 59/002
C07D 401/04
C07D 491/107
C07D 519/00
Filing Date
2025-08-26
Application No.
19309956