INHIBITORS OF ENL/AF9 YEATS AND FLT3
Application
US20260078121A1
Kind: A1
Mar 19, 2026
Inventors
Tammy Ladduwahetty, Joseph P. Vacca, Sébastien L. Degorce
Abstract
Compounds and pharmaceutical compositions comprising compounds that inhibit ENL/AF9 YEATS and FLT3 are disclosed herein. Methods for suppressing oncogene expression in a cell, or for treating acute leukemias, using the compounds and pharmaceutical compositions comprising the compounds are also disclosed. The compounds, pharmaceutical compositions and methods can be used to inhibit key drivers of cancer and cancer stem cell survival.
CPC Classifications
C07D 471/04
A61K 31/437
A61K 31/444
A61K 31/4545
A61K 45/06
A61P 35/02
Filing Date
2023-08-18
Application No.
19109792